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Endocrine System Senescence

Meaning

Endocrine System Senescence refers to the gradual, age-related decline in the structural integrity and functional capacity of the body’s hormone-producing glands and their respective feedback loops. This process involves reduced hormone synthesis, altered receptor sensitivity, and less precise regulatory control. Common clinical manifestations include somatopause, andropause, and menopausal transition, all characterized by measurable shifts in circulating hormone concentrations. Understanding and mitigating this physiological slowdown is central to longevity medicine and hormonal optimization strategies.