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Endocrine System Modulators

Meaning

Endocrine System Modulators (ESMs) are a diverse class of compounds, both synthetic and naturally derived, that interact with the body’s endocrine system to alter the synthesis, secretion, transport, binding, action, or elimination of endogenous hormones. These agents are clinically utilized to correct hormonal imbalances, treat hormone-dependent diseases, or prevent specific physiological effects. ESMs encompass a wide array of mechanisms, ranging from selective receptor binding to enzymatic inhibition, and include therapies like Selective Estrogen Receptor Modulators (SERMs) and aromatase inhibitors. Their use requires precise clinical monitoring to achieve the desired therapeutic effect while minimizing systemic disruption.