What is the Origin of Endocrine System Attrition?

This term is a clinical and longevity-focused conceptualization, combining 'endocrine system' (the network of hormone-secreting glands) with 'attrition,' a word derived from the Latin attritio (a rubbing against, or wearing away). It is used to describe the progressive, chronic loss of functional integrity within this critical regulatory network.

What is the Mechanism of Endocrine System Attrition?

The mechanism involves several age-related changes, including oxidative stress damaging glandular tissue and a reduction in the number or sensitivity of hormone receptors on target cells. Chronic inflammation also contributes by interfering with hormone synthesis and signaling pathways. This collective functional erosion leads to hormonal imbalances, such as reduced DHEA and growth hormone, impacting metabolic rate, energy, and overall tissue repair.

Endocrine System Attrition ∞ Area

Endocrine System Attrition

Meaning

Endocrine System Attrition refers to the gradual, cumulative decline in the functional capacity, sensitivity, and output of the body’s hormone-producing glands and their corresponding receptor sites over time. This age-related deterioration results in less precise hormonal signaling, blunted responses to stimuli, and a reduction in the overall hormonal reserve. It is a fundamental component of biological aging that contributes to systemic decline.