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Endocrine Suppression Rebound

Meaning

Endocrine Suppression Rebound describes the temporary but often intense overcompensation of a body’s native hormone production pathways following the abrupt cessation of an exogenous hormone therapy or a substance that artificially suppressed the system. This phenomenon is a consequence of the negative feedback loop within the hypothalamic-pituitary-gonadal (HPG) or hypothalamic-pituitary-adrenal (HPA) axes being suddenly removed. Clinically, it can lead to transient hormonal imbalances, manifesting as symptoms ranging from fatigue to mood disturbances until the endogenous production stabilizes.