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Endocrine-Skeletal Axis

Meaning

The Endocrine-Skeletal Axis describes the reciprocal signaling pathway between the skeletal system and the endocrine system, illustrating that bone is not merely a structural component but an active endocrine organ. This axis encompasses the production of hormones by bone cells, such as osteocalcin, and the influence of classical endocrine hormones, including parathyroid hormone, estrogen, testosterone, and growth hormone, on bone metabolism and density. Recognition of this axis is essential for understanding bone health beyond calcium metabolism and its systemic impact on energy balance.