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Endocrine Signaling Efficiency

Meaning

Endocrine Signaling Efficiency quantifies the biological effectiveness of hormonal communication, representing how readily a target cell translates a hormone signal into a measurable physiological response. This efficiency is a critical factor in healthspan, determined by the density and sensitivity of cellular receptors, the integrity of intracellular signal transduction pathways, and the clearance rate of the hormone itself. Declining efficiency, often seen with age or chronic stress, leads to systemic functional deficits despite adequate hormone production.