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Endocrine Signaling Drift

Meaning

Endocrine Signaling Drift describes the gradual, age-related deviation from the optimal, youthful rhythm and magnitude of hormonal communication, resulting in a progressive state of systemic dysregulation. This involves shifts in pulsatility, altered feedback loop sensitivity, and asynchronous communication between the central endocrine glands and their peripheral target tissues. The clinical consequence of this drift is often a non-specific decline in vitality, metabolic homeostasis, and reproductive function, characteristic of hormonal aging.