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Endocrine Sensitivity Index

Meaning

The Endocrine Sensitivity Index is a quantifiable metric designed to assess the responsiveness of peripheral target tissues to circulating hormone concentrations, moving beyond simple serum levels to evaluate functional endocrine status. This index measures the efficiency of hormone-receptor binding, intracellular signaling cascades, and subsequent cellular and physiological response. A low index suggests receptor downregulation or post-receptor signaling impairment, often seen in conditions like insulin resistance or hormonal aging, even when hormone levels are within the reference range. This advanced clinical tool is vital for precision dosing and personalized hormone therapy.