What is the Origin of Endocrine Recession?

The term is an analogy borrowed from economics, vividly illustrating the widespread, systemic decline in hormonal "capital" that occurs with chronological aging, often referred to as endocrinosenescence. It gained prominence in anti-aging medicine to frame the physiological state that precedes overt endocrinopathies but still significantly impairs quality of life. The clinical focus is on reversing this recession to restore youthful hormonal kinetics.

What is the Mechanism of Endocrine Recession?

The underlying mechanism involves both a decline in the secretory capacity of endocrine glands, such as the gonads and adrenal cortex, and a reduced sensitivity of target tissues to the remaining circulating hormones. Specific pathways include the age-related shortening of steroidogenic enzyme activity and the desensitization of hormone receptors. This combined glandular and peripheral failure creates a cascade effect, leading to a generalized slowing of metabolic and regenerative processes throughout the body.

Endocrine Recession ∞ Area

Endocrine Recession

Meaning

Endocrine Recession is a clinical term describing a state of systemic hormonal decline characterized by a significant, often age-related, reduction in the production and circulating levels of multiple key anabolic and regulatory hormones, such as DHEA, testosterone, estrogen, and growth hormone. This recession leads to a net catabolic state, contributing to sarcopenia, osteopenia, metabolic slowdown, and general loss of vitality. It is a defining feature of the aging process and a primary target for longevity interventions.