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Endocrine-Metabolic Network

Meaning

The Endocrine-Metabolic Network describes the highly integrated and bidirectional communication system that links the body’s hormone-secreting glands with its complex processes of energy production, utilization, and storage. This network encompasses key axes like the hypothalamic-pituitary-adrenal (HPA) axis, the thyroid axis, and the insulin-glucose regulatory system. It represents a master regulatory system that maintains systemic homeostasis, adapting physiological responses to internal and external demands. Dysfunction within this intricate network is a central feature of chronic conditions such as type 2 diabetes, obesity, and age-related hormonal decline.