Question 1

What is the Meaning of Endocrine Function of Muscle?

Accepted Answer

Skeletal muscle functions as an active endocrine organ, extending beyond locomotion. This involves muscle synthesizing and secreting various signaling molecules, called myokines, into the bloodstream. These factors act as hormones, influencing distant organs and participating in systemic physiological regulation.

Question 2

What is the Context of Endocrine Function of Muscle?

Accepted Answer

Skeletal muscle, the body's largest organ by mass, plays a central role in whole-body metabolism. Its endocrine activity positions it as a crucial communicator within the broader endocrine system. Myokines facilitate inter-organ crosstalk, impacting metabolic homeostasis, inflammation, and energy balance across various tissues.

Question 3

What is the Significance of Endocrine Function of Muscle?

Accepted Answer

Understanding muscle's endocrine function is vital for managing chronic metabolic diseases. This concept explains how regular physical activity exerts systemic benefits, improving insulin sensitivity and reducing chronic inflammation. It provides a physiological basis for exercise's therapeutic effects in conditions like type 2 diabetes and obesity.

Question 4

What is the Mechanism of Endocrine Function of Muscle?

Accepted Answer

Muscle contraction and exercise induce gene expression changes within muscle fibers, leading to the synthesis and release of specific myokines. These myokines, such such as irisin and IL-6, circulate in the bloodstream. Upon reaching target cells, they bind to receptors, triggering intracellular signaling that modulates metabolic and physiological processes.

Question 5

What is the Application of Endocrine Function of Muscle?

Accepted Answer

Clinically, this function underscores physical activity as a potent intervention for metabolic health. Tailored exercise prescriptions can optimize myokine release, contributing to improved glycemic control, enhanced lipid profiles, and reduced systemic inflammation. This approach supports lifestyle interventions as a foundational strategy in metabolic dysfunction management.

Question 6

What is the Metric of Endocrine Function of Muscle?

Accepted Answer

The effects of muscle's endocrine activity are assessed through various clinical and biochemical parameters. Indirect measures include improvements in glucose tolerance and insulin sensitivity indices. Direct assessment involves quantifying specific myokine levels in serum or plasma using specialized immunoassays, providing insight into muscle's systemic hormonal output.

Question 7

What is the Risk of Endocrine Function of Muscle?

Accepted Answer

Insufficient physical activity or a sedentary lifestyle diminishes beneficial myokine output, contributing to metabolic dysregulation and increased chronic disease susceptibility. Conversely, inappropriate or excessive exercise without proper guidance can lead to musculoskeletal injuries, potentially negating desired benefits. Muscle wasting conditions, like sarcopenia, inherently impair this endocrine function, worsening overall metabolic health.

Endocrine Function of Muscle

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

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