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Endocrine Function of Bone

Meaning

The Endocrine Function of Bone refers to the contemporary understanding that the skeletal system is not merely a structural framework and mineral reservoir but also a dynamic endocrine organ that secretes hormones to regulate distant organ function. This paradigm shift acknowledges that bone cells, particularly osteoblasts, produce and release signaling molecules that exert systemic effects on energy metabolism, fertility, and even brain function. The most prominent example of this function is the secretion of osteocalcin, a bone-derived hormone that acts on peripheral tissues. Appreciating this endocrine role is crucial for a holistic view of hormonal health and metabolic regulation.