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Endocrine Function Decline

Meaning

Endocrine Function Decline describes the physiological reduction in the synthesis, secretion, and subsequent biological action of hormones across the body’s ductless glands, typically observed with advancing age or pathology. This systemic shift encompasses both lower absolute circulating hormone levels and a simultaneous diminution of receptor sensitivity in target tissues, resulting in systemic dysregulation. Clinical manifestations frequently include a reduced basal metabolic rate, accelerated loss of bone mineral density, and compromised reproductive and immune functions. It is a defining characteristic of biological aging that impacts nearly every major physiological system.