A comprehensive, systematic clinical evaluation of the entire endocrine system, going beyond routine hormone panel testing to assess the interconnectedness and functional reserve of multiple glands and axes. This audit involves a detailed review of dynamic testing results, baseline hormone levels, metabolic markers, and clinical symptomatology to identify subtle dysfunctions or early stage hormonal imbalances. The purpose is to create a holistic functional map of the patient’s hormonal status for precision therapeutic planning. This integrated assessment provides a clear, actionable picture of endocrine health.
Origin
This is a modern term in functional and clinical endocrinology, borrowing the concept of an “audit” from systematic review and quality assurance processes. “Endocrine function” encompasses the full scope of hormonal signaling and feedback loops throughout the body. The term emphasizes a thorough, structured, and integrative approach to diagnostic assessment, acknowledging the complexity of the neuroendocrine network.
Mechanism
The audit mechanism involves a multi-tiered approach to data collection and analysis, beginning with comprehensive laboratory testing. This testing often includes not just total hormones but also free fractions, key metabolites, and binding globulins like SHBG. This is followed by an assessment of the regulatory axes, such as the HPA, HPT, and HPG axes, using dynamic tests like stimulation or suppression protocols. By cross-referencing these biochemical data points with the patient’s clinical history, the clinician can pinpoint the specific location and nature of the endocrine imbalance, distinguishing primary glandular failure from central regulatory issues.
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