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Endocrine Feedback Loop Gain

Meaning

Endocrine Feedback Loop Gain quantifies the sensitivity and responsiveness of a specific hormonal axis to fluctuations in the concentration of its output hormones. It is a measure of how aggressively the regulatory centers—typically the hypothalamus and pituitary gland—adjust their signaling in response to changes in peripheral hormone levels. A high gain indicates a very sensitive and tightly controlled system, while a low gain suggests sluggish or blunted responsiveness, often seen in conditions of chronic stress or endocrine senescence. Optimizing this gain is essential for maintaining robust hormonal homeostasis and adaptive capacity.