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Endocrine Feedback Failure

Meaning

Endocrine Feedback Failure describes the pathological inability of a hormonal system to appropriately adjust its secretory rate in response to circulating hormone levels or downstream physiological effects. This breakdown in the negative or positive feedback loop, which is central to endocrine regulation, leads to chronic hyper- or hyposecretion and subsequent systemic dyshomeostasis. The failure can originate at the level of the target gland, the pituitary, or the hypothalamus, resulting in a persistent and often progressive hormonal imbalance. Clinical symptoms manifest as the body loses its ability to self-regulate essential physiological processes.