Significant, discrete shifts or fluctuations in the secretion, metabolism, or receptor sensitivity of systemic hormones that impact physiological homeostasis or adaptation.
Origin
This terminology frames hormonal changes not as a static state but as dynamic occurrences within the body’s regulatory network. It emphasizes the importance of timing and magnitude of hormonal signals.
Mechanism
These events range from the acute pulsatile release of GnRH influencing the gonadal axis to the more prolonged changes induced by significant caloric restriction or intense physical exertion. Understanding the context surrounding these events allows clinicians to better interpret baseline hormone panels. Modulating the upstream signaling pathways, such as the pituitary-hypothalamic feedback loop, directly influences the frequency and character of these events.
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