Endocrine Downgrade describes a gradual, often subclinical, decline in the functional capacity or signaling efficiency of one or more endocrine glands or axes over time.
Origin
The nomenclature reflects the clinical observation of progressive functional impairment in hormonal systems associated with aging or chronic stress.
Mechanism
This downgrade often involves reduced hormone synthesis, impaired receptor affinity, or dysregulated negative feedback mechanisms within the hypothalamic-pituitary-target gland circuits.
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