What is the Origin of Endocrine-Disrupting Aging?

This nomenclature combines "endocrine disruption," referencing environmental interference with hormone action, with the concept of biological "aging." It highlights the role of chronic hormonal imbalance in the progressive decline of functional reserve.

What is the Mechanism of Endocrine-Disrupting Aging?

Disruptors operate by mimicking, blocking, or altering the synthesis and metabolism of endogenous hormones like estrogens, androgens, or thyroid hormones. Such interference can impair genomic stability and mitochondrial respiration within critical tissues. The resultant chronic low-grade endocrine dysfunction contributes to the overall aging phenotype.

Endocrine-Disrupting Aging ∞ Area

Endocrine-Disrupting Aging

Meaning

Endocrine-Disrupting Aging posits that cumulative exposure to exogenous or endogenous compounds that interfere with the endocrine system accelerates physiological senescence. This process involves subtle but persistent alterations in hormone signaling pathways, contributing to hallmarks of aging such as reduced metabolic flexibility and impaired tissue repair. We recognize this as a critical area in longevity science.