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Endocrine Decline Cascade

Meaning

The Endocrine Decline Cascade describes the progressive, often interrelated, deterioration in the function and output of the endocrine glands and their regulatory axes over time, typically associated with advancing age or chronic stress states. This cascade signifies a systemic drift away from youthful hormonal setpoints, impacting metabolic rate, body composition, and resilience to stressors. Recognizing this sequence is key to proactive longevity management in clinical endocrinology.