The comprehensive system of chemical communication within the body where glands secrete hormones directly into the bloodstream to target distant cells and tissues, coordinating metabolic function, growth, reproduction, and mood. This process ensures systemic homeostasis and adaptation to internal and external stimuli.
Origin
This term is a foundational concept of classical endocrinology, describing the primary function of the endocrine system as a slow, broadcast-style chemical signaling network, distinct from the rapid, localized electrical signaling of the nervous system. The “chemical regulation” component emphasizes the role of hormones as the signaling molecules.
Mechanism
Hormones, which are chemical messengers like steroids, peptides, or amines, bind to specific high-affinity receptors on or within target cells, triggering a cascade of intracellular events that alter cellular activity or gene transcription. The precision of this regulation relies on complex feedback loops involving the hypothalamus, pituitary, and peripheral endocrine glands, ensuring hormone levels remain within a tight physiological range.
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