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Endocrine Axis Interplay

Meaning

Endocrine Axis Interplay describes the complex, bidirectional communication and regulatory feedback loops occurring between different glands and hormonal systems within the body, such as the Hypothalamic-Pituitary-Adrenal (HPA) axis, the Hypothalamic-Pituitary-Gonadal (HPG) axis, and the Thyroid axis. Successful systemic homeostasis depends on the precise synchronization of these axes, where the output of one frequently modulates the sensitivity or secretion of another. Disturbances in this interplay are central to many chronic health conditions.