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Endocrine Axis Coupling

Meaning

Endocrine Axis Coupling refers to the complex, coordinated intercommunication and mutual regulatory influence that exists between two or more distinct neuroendocrine axes within the human body. This phenomenon underscores the fact that hormonal systems, such as the Hypothalamic-Pituitary-Adrenal (HPA) axis and the Hypothalamic-Pituitary-Gonadal (HPG) axis, are intricately linked and do not function in isolation. Proper coupling is absolutely essential for systemic adaptation, maintaining robust metabolic balance, and ensuring reproductive health. Dysregulation in one axis often leads to compensatory or detrimental changes in the coupled system.