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Endocrine Aging Acceleration

Meaning

The pathological or premature decline in the functional capacity and regulatory precision of the body’s endocrine glands and signaling axes, resulting in a hormonal profile disproportionately advanced for a person’s chronological age. This acceleration manifests as diminished hormone production, altered hormone ratios, and reduced target tissue sensitivity. It is a critical factor in the onset of age-related health issues, including sarcopenia, metabolic syndrome, and frailty. This state signifies a loss of endocrine resilience and adaptive capacity.