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Endocannabinoid System Balance

Meaning

Endocannabinoid System Balance refers to the optimal, homeostatic functional status of the Endocannabinoid System (ECS), a complex lipid signaling network that regulates numerous physiological processes, including energy balance, mood, appetite, and neuroprotection. A state of balance signifies the appropriate synthesis, degradation, and receptor signaling (primarily CB1 and CB2) of the body’s endogenous cannabinoids, ensuring precise, context-dependent regulation of metabolic and behavioral processes. Imbalance, or ECS dysregulation, is often implicated in conditions like metabolic syndrome and chronic pain.