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Enclomiphene Treatment

Meaning

Enclomiphene treatment involves the therapeutic use of enclomiphene citrate, which is the purified, non-estrogenic isomer of the drug clomiphene citrate, primarily for the treatment of secondary hypogonadism in men. This pharmacological agent selectively blocks estrogen receptors in the hypothalamus and pituitary gland, effectively preventing the normal negative feedback loop exerted by circulating estrogen. The resulting clinical effect is a significant increase in the pulsatile release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), leading to enhanced endogenous testosterone production. It is a preferred approach for men seeking to restore hormonal balance while concurrently preserving fertility and maintaining normal testicular size.