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Enclomiphene Pituitary Stimulation

Meaning

Enclomiphene Pituitary Stimulation is a targeted pharmacological strategy used in men to treat secondary hypogonadism by increasing the endogenous production of testosterone. Enclomiphene, the trans-isomer of clomiphene, acts as a selective estrogen receptor modulator (SERM) that specifically blocks estrogen receptors in the hypothalamus and pituitary gland. This action disrupts the negative feedback loop normally exerted by circulating estrogens, signaling the brain to boost gonadotropin release. The ultimate clinical goal is to restore physiological testosterone levels while preserving fertility and avoiding the testicular atrophy associated with exogenous testosterone administration.