ELITE Study ∞ Area

ELITE Study

Meaning

The ELITE Study, an acronym for Evaluation of Livalo in Elderly Subjects with Diabetes Mellitus and Elevated Triglycerides, was a pivotal clinical investigation. Its primary objective was to assess the efficacy and safety profile of pitavastatin, a statin medication, in managing dyslipidemia within a specific patient cohort. This research specifically focused on older individuals who were concurrently diagnosed with type 2 diabetes and presented with elevated triglyceride levels, a common and challenging metabolic presentation.

Context

This study operated within the broader clinical landscape of cardiovascular disease prevention and lipid management, particularly for populations with heightened metabolic risk. It aimed to clarify the role of pitavastatin in optimizing lipoprotein profiles in patients where diabetes contributes significantly to atherosclerotic progression. Understanding pharmacological interventions for dyslipidemia in this vulnerable demographic is essential for comprehensive health management and mitigating long-term complications.

Significance

The ELITE Study holds considerable clinical significance by contributing robust evidence for guiding therapeutic decisions in older adults with type 2 diabetes and hypertriglyceridemia. Its findings provided valuable insights into the tolerability and metabolic impact of pitavastatin within this patient group, informing clinicians about appropriate lipid-lowering strategies. This evidence supports personalized treatment approaches, aiming to reduce cardiovascular morbidity and improve overall patient well-being.

Mechanism

The mechanism investigated within the ELITE Study pertains to pitavastatin’s action as an HMG-CoA reductase inhibitor. This enzymatic inhibition directly reduces the rate-limiting step in cholesterol biosynthesis within hepatic cells. Consequently, this leads to an upregulation of low-density lipoprotein (LDL) receptors on hepatocyte surfaces, enhancing the clearance of circulating LDL cholesterol. This process effectively lowers plasma levels of total cholesterol, LDL-C, and very-low-density lipoprotein (VLDL) derived triglycerides.

Application

The practical application of the ELITE Study’s outcomes involves informing the clinical prescription of pitavastatin for elderly patients with type 2 diabetes and concurrent elevated triglyceride levels. Healthcare providers utilize these data to select an appropriate statin therapy, considering the patient’s age, co-morbidities, and potential for drug interactions. The study supports an evidence-based approach to managing complex dyslipidemia in a demographic often requiring nuanced therapeutic considerations.

Metric

The effects of the intervention in the ELITE Study were rigorously measured through a comprehensive array of biochemical metrics. Primary endpoints included changes in serum lipid parameters such as total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. Additionally, safety and tolerability were assessed by monitoring liver enzyme levels, creatine kinase, and glycemic control markers like glycated hemoglobin (HbA1c) throughout the study duration to ensure patient safety.

Risk

While the medication evaluated in the ELITE Study, pitavastatin, generally demonstrates a favorable safety profile, potential clinical risks exist, as with any pharmacological agent. These risks include the possibility of muscle-related adverse events, ranging from myalgia to, in rare instances, rhabdomyolysis. Hepatic enzyme elevations can also occur. Careful patient selection, vigilant monitoring of laboratory parameters, and assessment for drug interactions are crucial to mitigate these risks, particularly in an elderly population with multiple health considerations.

A bioidentical hormone pellet, central to Hormone Replacement Therapy, rests on a porous structure, symbolizing cellular matrix degradation due to hormonal imbalance. This represents precision hormone optimization, vital for restoring biochemical balance, addressing menopause, andropause, and hypogonadism.

Are There Studies on HRT and Extreme Longevity?

Studies suggest a link between HRT and increased longevity, particularly when initiated early in menopause, by modulating age-related inflammation.

∞ Aging Process
∞ Hormone Replacement
∞ Estrogen Therapy

HRTioJuly 29, 2025

ELITE Study

Meaning

Context

Significance

Mechanism

Application

Metric

Risk

Are There Studies on HRT and Extreme Longevity?

Provided by the clinical team
at 4Ever Young Miami Dadeland

-15% ∞ HRTIO15

Your protocol begins with a conversation.

Visit

Schedule Appointment

About

Med & Wellness

4Ever Young Miami Dadeland

Communication

+1 786-529-6686

Email Us

Opening Hours