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Elimination Half-Life

Meaning

Elimination half-life, denoted as t1/2, is a fundamental pharmacokinetic parameter that represents the time required for the concentration of a substance, such as a hormone or medication, in the systemic circulation to decrease by fifty percent. This metric is clinically vital for determining the appropriate dosing frequency and time required to reach a steady-state concentration during therapeutic administration. A longer half-life permits less frequent dosing, while a shorter one necessitates more frequent administration to maintain stable levels.