A measure of the duration of an individual’s life during which they retain high-level cognitive function and executive capacity to make sound, complex, and impactful life decisions. This metric transcends mere physical longevity, focusing instead on the preservation of neurocognitive health and hormonal milieu necessary for independent and high-quality agency. It is a critical endpoint in longevity medicine, reflecting the sustained integrity of the neuroendocrine system.
Origin
This term is an evolution of the concept of ‘healthspan,’ moving the focus from general well-being to the specific cognitive capacity required for self-determination and strategic life planning. It bridges gerontology, cognitive neuroscience, and endocrinology, acknowledging the role of hormones in modulating prefrontal cortex function.
Mechanism
Sustaining the Effective Decision Lifespan relies on optimizing factors that protect neuronal health, such as balanced sex steroid and thyroid hormone levels, and minimizing chronic neuroinflammation. Adequate brain energy metabolism and efficient neurotransmitter synthesis, supported by optimal hormonal signaling, are foundational. The mechanism involves the persistent function of the hypothalamic-pituitary axis to maintain cognitive resilience against age-related decline.
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