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Ectopic Fat Accumulation

Meaning

Ectopic Fat Accumulation is the pathological deposition of triglycerides within non-adipose tissues, such as the liver, skeletal muscle, heart, and pancreas, where fat is not normally stored in large quantities. This misplacement of lipid droplets is highly detrimental, as it directly interferes with the normal function of these vital organs, leading to cellular stress and organ dysfunction. This accumulation is a significant metabolic risk factor closely linked to insulin resistance, type 2 diabetes, and cardiovascular disease, profoundly disrupting endocrine signaling pathways. Managing systemic metabolic health is key to preventing this damaging visceral and organ fat deposition.