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Dynorphin

Meaning

Dynorphin is a potent endogenous opioid peptide that functions as a neuromodulator and neurotransmitter within the central nervous system, particularly in regions governing pain, stress, and emotion. Derived from the precursor protein prodynorphin, this peptide exerts its primary biological effects by selectively binding to and activating the kappa-opioid receptor (KOR). Dynorphin plays a critical, often dysphoric, role in the body’s intrinsic stress response and is implicated in the modulation of pain perception and mood states. High concentrations are often associated with conditions of chronic stress and withdrawal, contrasting with the euphoric effects of other endorphins.