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Dutasteride Pharmacokinetics

Meaning

Dutasteride pharmacokinetics describes the quantitative study of how the body handles the drug dutasteride, encompassing its absorption, distribution, metabolism, and excretion (ADME) over time. This compound is a dual 5-alpha reductase inhibitor, blocking both Type 1 and Type 2 isoforms of the enzyme responsible for converting testosterone to the more potent dihydrotestosterone (DHT). Key pharmacokinetic characteristics include its high oral bioavailability, extensive tissue distribution, primary metabolism via the CYP3A4 enzyme, and an exceptionally long terminal half-life, which necessitates a careful dosing strategy and highlights the extended duration of its biological effect.