Question 1

What is the Meaning of DURATION-1 Study?

Accepted Answer

The DURATION-1 Study was a pivotal, long-term randomized clinical trial designed to evaluate the efficacy and safety of exenatide administered once weekly for the management of Type 2 Diabetes Mellitus. This investigation compared the once-weekly formulation of the drug against the twice-daily injection regimen, measuring primary endpoints like changes in glycated hemoglobin (HbA1c) and body weight. The study provided critical evidence supporting the sustained metabolic and glycemic improvements achieved with the long-acting glucagon-like peptide-1 receptor agonist (GLP-1RA). It established a foundation for extended-release pharmacological interventions in endocrinology.

Question 2

What is the Origin of DURATION-1 Study?

Accepted Answer

The study originated in the early 2000s as part of the pharmaceutical development program for exenatide, a synthetic version of exendin-4, a peptide initially isolated from the saliva of the Gila monster lizard. Its name, DURATION, is an acronym reflecting the therapeutic goal: Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly. This was one of the first major trials to demonstrate the long-term clinical benefits of a weekly GLP-1 mimetic.

Question 3

What is the Mechanism of DURATION-1 Study?

Accepted Answer

The observed therapeutic effects are mediated by the drug's action as a GLP-1 receptor agonist, which mimics the activity of the endogenous incretin hormone. The weekly formulation maintains sustained plasma concentrations of exenatide, which then binds to the GLP-1 receptors on pancreatic beta cells to enhance glucose-dependent insulin secretion. Simultaneously, it suppresses inappropriate glucagon release from alpha cells and slows gastric emptying, leading to improved postprandial glucose control and a clinically significant reduction in body weight.

DURATION-1 Study

Meaning

Origin

Mechanism

What Are the Long-Term Outcomes of Peptide Therapy for Glucose Control?

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