DunedinPACE Velocity is a novel, single-time-point measure of the pace of biological aging, quantifying the rate at which an individual’s body is deteriorating relative to the chronological passage of time. Unlike static measures of biological age, which estimate the current age of the body, the ‘Velocity’ component provides a dynamic metric of aging acceleration or deceleration. A velocity greater than 1.0 indicates accelerated aging, while a velocity less than 1.0 suggests a slower, more favorable aging trajectory. This advanced biomarker is a powerful tool for monitoring the effectiveness of longevity interventions in a clinical setting.
Origin
The term is derived from the Dunedin Multidisciplinary Health and Development Study, a seminal longitudinal cohort study in New Zealand, and PACE, which stands for “Pace of Aging Calculated from the Epigenome.” This sophisticated biomarker leverages epigenetic data, specifically DNA methylation patterns, to calculate the rate of change in biological systems. Its origin lies in the intersection of longitudinal epidemiology and epigenetic clocks, providing a data-driven metric for personalized longevity medicine.
Mechanism
The calculation relies on a specific algorithm that analyzes thousands of DNA methylation sites across the genome, identifying patterns associated with changes in the function of multiple organ systems over time. It essentially models the rate of decline observed in a composite of clinical biomarkers, including kidney, liver, metabolic, and immune system parameters. By translating these methylation patterns into a rate of change, it provides a highly sensitive, forward-looking assessment of an individual’s physiological health trajectory.
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