What is the Origin of DunedinPACE?

This biomarker was developed by researchers using longitudinal data from the Dunedin Multidisciplinary Health and Development Study, a cohort of individuals born in Dunedin, New Zealand, who have been followed from birth. Its unique design emerged from the need for a measure that was responsive to lifestyle and clinical interventions, capable of detecting subtle changes in the pace of aging over short time periods.

What is the Mechanism of DunedinPACE?

DunedinPACE is calculated by analyzing patterns of DNA methylation at specific CpG sites across the genome, a process regulated by the epigenome. The algorithm integrates data from numerous physiological systems and is specifically trained on changes in 19 different biomarkers of organ system integrity, including cardiovascular, metabolic, and renal function. This composite measurement reflects the overall systemic stress and functional decline independent of chronological age.

DunedinPACE ∞ Area

DunedinPACE

Meaning

DunedinPACE, which stands for Pace of Aging Computed from the Epigenome, is a cutting-edge epigenetic biomarker that functions as a molecular speedometer for the human aging process. Unlike traditional epigenetic clocks that estimate a person’s biological age at a single point in time, DunedinPACE quantifies the rate at which an individual is currently aging, expressed as years of biological aging per calendar year. This metric provides an actionable, dynamic measure of physiological decline.

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Your Biological Age Is Your True North

Your biological age is the only metric that matters; engineer it to build a body that defies the calendar.

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HRTioOctober 7, 2025

Aging Is a Program You Can Edit

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Which Specific Lab Tests Can Measure My Personal Epigenetic Response to Lifestyle Changes?

Specific lab tests measuring DNA methylation and histone modifications offer a window into how lifestyle sculpts gene expression, empowering personalized wellness.

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HRTioAugust 26, 2025

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DunedinPACE

Meaning

Origin

Mechanism

Your Biological Age Is Your True North

Which Specific Lab Tests Can Measure My Personal Epigenetic Response to Lifestyle Changes?

What Specific Lab Tests Might Indicate How My Lifestyle Is Influencing My Gene Expression for Hormones?

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