What is the Origin of Dunedin PACE?

The term is a proprietary clinical metric, named after the Dunedin Study cohort in New Zealand, where the foundational data was collected, and the acronym PACE. It represents a sophisticated advancement in the field of geroscience, moving beyond static biological age to measure the velocity of aging.

What is the Mechanism of Dunedin PACE?

The calculation is based on an algorithm that analyzes the methylation status of thousands of specific CpG sites across the human genome, capturing subtle, dynamic changes in epigenetic marks. These methylation patterns are integrated to provide a measure of physiological decline across multiple organ systems, offering a more comprehensive assessment of systemic health than traditional biomarkers alone.

Dunedin PACE ∞ Area

Dunedin PACE

Meaning

Dunedin PACE is a novel, highly sensitive measure of the Pace of Aging Calculated from the Epigenome, derived from longitudinal data collected in the Dunedin Multidisciplinary Health and Development Study. This epigenetic clock is designed to quantify the rate at which an individual’s biological systems are deteriorating over time, expressed as years of biological aging per chronological year. A value greater than 1.0 indicates accelerated aging, which is strongly linked to hormonal and metabolic decline.