What is the Origin of Dual Trigger Protocol?

The term arose within the field of reproductive endocrinology as a refinement of ovulation induction techniques. It addresses the clinical observation that a more physiological LH surge, which includes a component of FSH activity, is necessary for complete cytoplasmic and nuclear maturation of the oocyte. This protocol reflects an advancement in precision medicine for fertility treatment.

What is the Mechanism of Dual Trigger Protocol?

The GnRH-a component acutely stimulates the pituitary gland to release endogenous LH and FSH, mimicking the natural pre-ovulatory surge. Concurrently, the hCG component, which acts as a long-acting LH analog, provides sustained luteal support necessary for endometrial receptivity and corpus luteum function. This synergistic action ensures the optimal timing and hormonal milieu for successful oocyte retrieval and subsequent embryo development.

Dual Trigger Protocol ∞ Area

Dual Trigger Protocol

Meaning

The Dual Trigger Protocol is a specialized clinical strategy utilized in assisted reproductive technology (ART), specifically during in vitro fertilization (IVF), involving the co-administration of two distinct hormonal agents to induce final oocyte maturation. This method typically combines a Gonadotropin-Releasing Hormone agonist (GnRH-a) with human Chorionic Gonadotropin (hCG) to stimulate a more comprehensive and physiologically relevant surge of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). The goal is to optimize the quantity and quality of mature oocytes retrieved, particularly in patients who exhibit a suboptimal response to traditional hCG-only triggers.