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Dual-Agonist

Meaning

A pharmacological agent designed to simultaneously activate two distinct, specific cellular receptors, often belonging to different hormone or peptide families, to achieve a synergistic or more comprehensive therapeutic effect. In endocrinology and metabolic health, these compounds are engineered to target two key pathways, such as the Glucagon-like Peptide-1 (GLP-1) receptor and the Glucose-dependent Insulinotropic Polypeptide (GIP) receptor, to enhance glucose homeostasis and promote weight management. This dual action aims to leverage the body’s natural physiological feedback loops more effectively than a single-receptor agonist.