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Drug-Supplement Interaction

Meaning

A Drug-Supplement Interaction is a clinical event where an over-the-counter dietary supplement, botanical extract, or natural compound alters the absorption, metabolism, or action of a co-administered pharmaceutical drug. This complex interaction can result in two primary unintended consequences: a reduction in the drug’s intended therapeutic efficacy or a dangerous potentiation of its effects, potentially leading to increased toxicity. A thorough clinical assessment of all concurrent therapies is therefore mandatory for ensuring patient safety and treatment success.