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Drug Response Variability

Meaning

Drug Response Variability describes the wide spectrum of clinical outcomes observed among different individuals when receiving the same therapeutic agent, ranging from complete efficacy to non-response or the development of adverse side effects. In hormonal health, this phenomenon is particularly relevant because endocrine-modulating drugs, such as hormone replacement therapies or aromatase inhibitors, are profoundly affected by individual metabolic, genetic, and epigenetic profiles. Understanding the sources of this variability is essential for achieving true precision medicine, allowing clinicians to tailor drug selection and dosage to maximize therapeutic benefit and minimize risk for each patient. This variability underscores the inadequacy of a one-size-fits-all approach to endocrine treatment.