Question 1

What is the Meaning of Drug-Nutrient Interaction?

Accepted Answer

A Drug-Nutrient Interaction is a reciprocal biochemical or physiological event where an administered medication alters the body's absorption, metabolism, utilization, or excretion of a nutrient, or conversely, a nutrient affects the efficacy or toxicity profile of a drug. These interactions can significantly impact both the therapeutic outcome of the medication and the patient's nutritional status. Recognizing these effects is essential for safe and effective clinical management.

Question 2

What is the Origin of Drug-Nutrient Interaction?

Accepted Answer

This is a clinical and pharmacological term that describes the interplay between a therapeutic agent (Drug) and essential dietary components (Nutrient). The concept has evolved with the understanding of human metabolism and the complex pathways shared between exogenous compounds and endogenous substances. It highlights the importance of diet in the context of pharmacotherapy.

Question 3

What is the Mechanism of Drug-Nutrient Interaction?

Accepted Answer

Interactions can occur via several mechanisms, including chelation in the gastrointestinal tract that prevents nutrient absorption, or competition for transport proteins across cell membranes. A common mechanism involves the induction or inhibition of shared hepatic enzyme systems, such as the Cytochrome P450 enzymes, which metabolize both drugs and nutrients. This competition can lead to sub-therapeutic drug levels or, conversely, increased drug toxicity or nutrient depletion.

Drug-Nutrient Interaction

Meaning

Origin

Mechanism

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