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Drospirenone

Meaning

Drospirenone is a synthetic, fourth-generation progestin widely incorporated into hormonal contraceptives and menopausal hormone therapy, recognized for its unique pharmacological profile. Chemically derived from spironolactone, it possesses significant antimineralocorticoid activity, which helps counteract the fluid retention and bloating often associated with estrogen and other progestins. Furthermore, it exhibits potent antiandrogenic effects, making it a valuable agent for managing symptoms such as acne and hirsutism in women with androgen excess. Its clinical utility stems from its ability to provide effective contraception while mitigating common, undesirable side effects related to water balance and androgenic stimulation.