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Double-Blind Placebo Controlled

Meaning

A rigorous clinical trial design considered the gold standard in evidence-based medicine, wherein neither the study participants nor the research investigators administering the intervention and assessing the outcomes are aware of who receives the active treatment and who receives the inert placebo. This methodology is essential for minimizing conscious and unconscious bias from both patient expectation and investigator interpretation, thereby isolating the true physiological effect of the intervention. It provides the highest level of confidence in attributing observed changes to the hormonal agent under investigation.