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Dosing Frequency Optimization

Meaning

Dosing Frequency Optimization is the clinical strategy of determining the ideal time interval between successive doses of a hormonal agent to maintain therapeutic plasma concentrations and minimize supraphysiological peaks and troughs. This pharmacokinetic adjustment is vital for mimicking the body’s natural, often pulsatile, endocrine secretion patterns. The goal is to achieve stable biological signaling that promotes continuous tissue response without causing receptor desensitization or cyclical side effects. Precision in this area directly impacts the effectiveness and tolerability of hormonal replacement or modulation therapies.