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Dose-Dependent Signaling

Meaning

Dose-dependent signaling describes the physiological principle where the magnitude of a biological response is directly proportional to the concentration, or dose, of the signaling molecule, such as a hormone or a drug. This relationship is fundamental to endocrinology, where a small change in circulating hormone levels can produce a significant, predictable shift in cellular function. Understanding the precise dose-response curve is paramount for clinical intervention, ensuring therapeutic efficacy while minimizing adverse effects. This principle guides the precise titration of hormonal therapies to achieve a targeted physiological outcome.