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Dose-Dependent Neurotoxicity

Meaning

Dose-Dependent Neurotoxicity describes the phenomenon where a substance, whether an endogenous hormone, pharmaceutical agent, or environmental toxin, causes damage or functional disruption to the nervous system in a manner directly correlated with the concentration or cumulative exposure level. In the context of hormonal health, this concept is critical for understanding the risks associated with both deficient and supraphysiological levels of hormones and their synthetic analogues. Clinical practice necessitates precise dosing to achieve therapeutic benefit while strictly avoiding the threshold at which neurotoxic effects, such as cognitive impairment or mood dysregulation, begin to manifest.