The dorsal hippocampus, often referred to as the septal pole, is the superior portion of the hippocampus, a major structure in the medial temporal lobe of the brain critical for learning and memory formation. In clinical and physiological contexts, this region is primarily associated with cognitive functions, including spatial navigation and declarative memory. It is a highly plastic area whose function is significantly modulated by circulating sex and stress hormones.
Origin
The term is anatomical, derived from the Latin words ‘dorsalis’ (relating to the back or upper side) and ‘hippocampus’ (sea horse), due to its curved shape. The hippocampus has been recognized for centuries, but the functional distinction between its dorsal and ventral parts is a concept established in modern neuroscience research. This regional specialization helps delineate different cognitive and emotional processing pathways.
Mechanism
This region contains a high density of receptors for various hormones, including glucocorticoids and estrogen, which influence neuronal excitability and synaptic plasticity, the biological basis of learning. Hormonal fluctuations, such as those seen during the female reproductive cycle or periods of chronic stress, directly impact the structure and function of dendritic spines in the dorsal hippocampus. The integrity of this structure is essential for stress resilience and preventing cognitive decline associated with hormonal aging.
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