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Dopamine Sensitivity Recalibration

Meaning

A therapeutic process aimed at restoring the optimal functional responsiveness of dopamine receptors within the mesolimbic and mesocortical pathways of the brain following chronic overstimulation or depletion. The goal is to re-establish a healthy baseline sensitivity, allowing for normal reward processing, motivation, and focus without requiring excessive or constant external stimuli. This recalibration is central to overcoming hedonic adaptation and improving baseline mood.