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Dopamine Cofactor

Meaning

A Dopamine Cofactor is a non-protein chemical compound, typically a vitamin or mineral, that is absolutely required for the enzymatic synthesis of the neurotransmitter dopamine within the brain and peripheral nervous system. The most recognized and critical cofactor is tetrahydrobiopterin, or BH4, which assists the rate-limiting enzyme tyrosine hydroxylase in converting tyrosine into L-DOPA. Other essential cofactors include Vitamin B6 and Magnesium, which are necessary for subsequent steps in the catecholamine synthesis cascade. Adequate availability of these cofactors is paramount for maintaining optimal dopaminergic tone, which governs motivation, reward, and executive function.